Notes on Thrombolytic systems

from text of barnett et al. c 9 Keyt et al.
t-PA inhibits conversion of plasminogen to plasmin, and plasmin , and fibrin clot, which is formed by the action of thrombin on fibrinogen, is dissolved by plasmin. Plasmin also feedback activates t-PA and enhances conversion into double chain form. Activation of system leads to a cascade leading to production of thrombin.

Arterial and venous clot are morphologically different (red v. white clot) but difference is more quantitative than qualitative. t-PA works much better on fibrin rich clots than on platelet rich white clots.