t-PA miscellany

1) In the NIHSS trial, those with score >20 had 17 % chance of bleeding compared to 3 % with a score less than ten 2) 0.6 mg/kg is considered an acceptable bridging dose 3)MERCI study (Stroek 2005:36:1432-1440) looked at patients up to 8 hours. The device is FDA approved the criteria are not. 46 % recanalized in the ITT analysis. Procedural complications occurred in 7 % and SICH in 7.1 %, Modified Rankin < 2 at 90 days was more common in those recanalized than those not recanlized (46 v. 10 %). 4) Brott 1992 t-pa risk but not efficacy increases with higher doses of t-pa. 5)