PT measures extrinsic and common pathways, is sensitive to low levels of Factors 7,10, tissue factor
intrinsic pathway - includes factors 8,9,11,12 also prekallikrein
PTT is elevated if deficient factors 8,9, also SLE, heparin tx
PTT is low in hypercoagulable state
Common pathway includes Factors V, X, prothrombin and fibrinogen
VWB disease- VWF depends on ristocetin induced aggluctination, decreased Factor 8, False positive occurs in inflammation, pregnancy, estrogen therapy
Vitamin K dependent factors decreased by coumadin include : extrinsic
prothrombinm F VII, F X but not VIII,XI, XII
intrinsic pathway - includes factors 8,9,11,12 also prekallikrein
PTT is elevated if deficient factors 8,9, also SLE, heparin tx
PTT is low in hypercoagulable state
Common pathway includes Factors V, X, prothrombin and fibrinogen
VWB disease- VWF depends on ristocetin induced aggluctination, decreased Factor 8, False positive occurs in inflammation, pregnancy, estrogen therapy
Vitamin K dependent factors decreased by coumadin include : extrinsic
prothrombinm F VII, F X but not VIII,XI, XII
No comments:
Post a Comment