Statins prevent vasospasm after subarachnoid hemorrhage

McGirt Mj et al. J Neurosurg 2006; 105: 671-674. (Duke) 115 patients were retrospectively reviewed with multivariate regression analysis. Statin therapy started on admission with SAH resulted in a elevenfold decrease in vasospasm. ACA/ICA aneurysm also was associated with vasospasm. Tseng MY al (Stroke 2005; J Neurosurg 2007) also published 2 articles on the subject . The mechanism is thought to be cholesterol independent, perhaps related to nitrous oxide.