O"Regan C, Wu P, Arora P, et al. Am J Med 2008; 121:24-33.
High points: the pooled relative risk of statin therapy for all cause mortality was 0.88 (95% CI .79-.91). Each unit increase in LDL results in a .3% increased RR of death. ONLY ONE TRIAL WAS FOR SECONDARY PREVENTION.
Details: RR of statin patients in all pooled trials, for cardiovascular death, .81, for nonhemorrhagic cerebrovscular death, .81, hemorrhagic stroke , 0.94, and fatal strokes .99. Be cautious of hemorrhagic strokes.
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