De Silva DA et al. Neurology 2011; 76:1838-1840.
General points
1. Some guidelines suggest 90 days not to use t-pa, but risk exists only in those with transmural MI (for cardiac rupture) and in those cases the wall is healed within 7 weeks, or at least healing, with fibrosis and scarring maximized by then, to mitigate risk in younger stroke patients without transmural rupture.
2. There are only 3 reports of 5 elderly women with tamponade after stroke thrombolysis.
3. In cardiac literature, wall rupture occurs in first 48 hours in those with transmural MI.
General points
1. Some guidelines suggest 90 days not to use t-pa, but risk exists only in those with transmural MI (for cardiac rupture) and in those cases the wall is healed within 7 weeks, or at least healing, with fibrosis and scarring maximized by then, to mitigate risk in younger stroke patients without transmural rupture.
2. There are only 3 reports of 5 elderly women with tamponade after stroke thrombolysis.
3. In cardiac literature, wall rupture occurs in first 48 hours in those with transmural MI.
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